Magnesium and its Health benefits

- Magnesium
- 03 May 2023
Overview
What is Magnesium?
Magnesium is a vital plentiful mineral in our body. It is crucial for the brain, bone functioning, and overall body fitness. It is found in a variety of natural foods.1Overview| Researched based study from Sciencedirect.com

Facts of magnesium
- Magnesium stands fourth among the most abundant mineral in our body
- Around half of the body’s magnesium is in our bones.
- Magnesium is required in around 600 enzymatic reactions of our body
- Magnesium is available in fortified products and as health supplements2Overview| Researched based study from Nlm.nih.gov
Sources
Sources of magnesium
Plant sources
- Spinach
- Broccoli
- Potato
- Pumpkin seeds
- Peanuts
- Black beans
- Kidney beans
- Carrot
- Soymilk
- White rice
- Brown rice
- Papaya
- Avocado
- Almond
- Cashew
- Apple
- Banana
- Blackberries
- Dried figs
- Fortified cereals
- Whole wheat bread
- Oatmeal
- Raisins
- Dark chocolate
Animal sources
- Salmon
- Milk
- Chicken breast
- Beef
- Dairy products
- Yogurt
Natural sources
- Normal tap water
- Packaged mineral water1Sources| Researched based study from Sciencedirect.com
Dosage
Dosage of magnesium
The recommended daily intake of magnesium in different age groups is as follows
Children
- Age 1-3 years-80 mg
- Age 4-8 years-130 mg
- Age 9-13 years-240 mg
Adolescent
Age 14-18 years
- Male- 410mg
- Female-360 mg
Adults
Age 19-30 years
- Male – 400 mg
- Female- 310 mg
Age 31-50 years
- Male- 420 mg
- Female- 320 mg
Age 51 years and above
- Male-420 mg
- Female-320 mg
Pregnant woman
- Age below 19 years-400 mg
- Age 19 -30 years-350 mg
- Age 31 years and above- 360 mg
Nursing mothers
- Age below 19 years- 360 mg
- Age 19-30 years- 310 mg
- Age 31 years and above- 320 mg3Dosage| Researched based study from Nih.gov
Benefits

Benefits of magnesium in our body
In regulating body functions
- Magnesium is involved in DNA (deoxyribonucleic acid) and RNA(ribonucleic acid)synthesis and bone development.
- It participates in the creation of energy.
- It plays a vital role in the transport of potassium and calcium across cell membranes.
- It maintains a regular heartbeat, muscle contraction, and nerve impulses, i.e., sending sensation to the brain following external stimulation.
- It nullifies the stomach acid and helps in passing stool through the intestine.
Regulates blood sugar
- It decreases the risk of type 2 diabetes
- It increases insulin sensitivity (the body can utilize the blood glucose effectively)4Benefits| Researched based study from Nlm.nih.gov
Help fight depression
- Magnesium reduces the symptoms of depression5Benefits| Researched based study from Nlm.nih.gov
- It enhances the mood
Prevent migraine attacks
- It prevents migraine attacks
- It relieves the severe migraine headache quickly6Benefits| Researched based study from Nlm.nih.gov
Enhances exercise performance
- It increases muscle mass and energy
- It improves the body’s movement7Benefits| Researched based study from Nlm.nih.gov
Increases the anti-inflammatory effect
- It reduces oxidative stress in the body
- It decreases the markers of inflammation (Markers of inflammation viz; C-reactive protein and interleukin-6 increase during any body injury)8Benefits| Researched based study from Nlm.nih.gov
Enhances bone health
- It increases the bone mineral density
- It decreases the risk of bone fractures9Benefits| Researched based study from Nlm.nih.gov
Enhances heart health
- Magnesium lowers the blood pressure
- It lowers the risk of stroke (bleeding in the brain’s blood vessels)10Benefits| Researched based study from Nlm.nih.gov
Improves premenstrual symptoms
- Magnesium reduces abdominal pain
- It decreases migraine attacks
- It decreases anxiety and depression
However, more research is warranted to prove the effect of magnesium on premenstrual symptoms.11Benefits| Researched based study from Nlm.nih.gov
Decreases anxiety
- It decreases the symptoms of anxiety
- It decreases stress and nervousness 12Benefits| Researched based study from Nlm.nih.gov
Promotes good sleep
- It improves the sleep quality
- It decreases the time to fall asleep13Benefits| Researched based study from Nlm.nih.gov
Side effects
Side effects of magnesium
- Abdominal pain
- Nausea and vomiting
- Diarrhea
- Weight loss
- Electrolyte(body minerals) imbalance14Side effects | Researched based study from Nlm.nih.gov
Overdose
Overdose toxicity of magnesium
- Extreme tiredness
- Depression
- Diarrhea
- Nausea and vomiting
- Stomach pain
- Low blood pressure
- Kidney problem
- Breathing difficulty
- Loss of central nervous system control
- Confusion
- Cardiac arrest (heart suddenly stops pumping blood around the body)
- Coma( prolonged loss of body consciousness)
- Death15Overdose | Researched based study from Nlm.nih.gov
Deficiency
Magnesium deficiency
Deficiency symptoms
- Extreme tiredness
- Nausea and vomiting
- Appetite loss
- Sleep difficulty
Severe deficiency causes
- Itchiness
- Muscle pain
- Irregular heartbeat
- Seizures (uncontrolled body shaking)
- Loss of sensation in body parts
- Personality changes16Deficiency| Researched based study from Sciencedirect.com
People prone to magnesium deficiency
People with the following health condition are prone to magnesium deficiency.
- Aged people
- Kidney disease
- Heart disease
- Parathyroid disorder (abnormal calcium level in blood)
- Crohn’s disease (a disease causing swelling and pain in the digestive tract)
- Migraine (headache)
- Alcoholism(addicted to alcohol)
- Diabetes(high blood sugar)
- Alzheimer’s disease(a brain disease causing memory loss)
- Gastrointestinal disorders(diseases involving the digestive tract)
- Cancer (abnormal cell growth in the body)17Deficiency | Researched based study from Nih.gov
Interactions
Drug interaction with magnesium
Levodopa
- Levodopa is used for treating Parkinson’s disease
- Taking magnesium oxide with levodopa decreases the efficiency of the drug
Tetracycline antibiotic
- Taking magnesium and tetracycline togetherdecreases the body’s absorption capacity and reduces the effectiveness of the drug
- So, one must take tetracycline antibiotics 2 hours before or 6 hours after magnesium consumption.
Quinolone antibiotic
- Taking magnesium and quinolone together decreases the body’s absorption capacity and reduces the efficiency of the quinolone
- So quinolone must be consumed 2 hours before or 5-6 hours after magnesium consumption.
Aminoglycoside antibiotic
- Taking magnesium and aminoglycoside together causes muscle problem
Bisphosphonates
- Taking magnesium and bisphosphonates together reduces the blood levels of biphosphonates and minimizes the bisphosphonate’s effectiveness
- So, bisphosphonates should be consumed 2hours before magnesium consumption
Muscle relaxant
- Magnesium relaxes the muscles
- So consuming magnesium and muscle relaxant together increases the side effect of the drug
Anticoagulant (blood thinning medicine)
- Magnesium delays the blood clotting
- Taking magnesium and anticoagulant together increases the risk of profuse bleeding
Water pills
- Water pills increase the magnesium in the body
- Taking magnesium and water pills together can lead to excess magnesium in the body
Calcium channel blockers
- Calcium channel blockers are used to treat high blood pressures. they obstruct calcium from entering the cells
- Magnesium also blocks calcium from entering the cells
- Taking magnesium and Calcium channel blockers together might cause an excessive decrease in blood pressure
Lanoxin
- Lanoxin is used to treat irregular heartbeat
- Taking magnesium and linoxin together decreases the lanoxin levels in the blood and reduces the effect of the drug
Diabetes medication
- Taking magnesium and diabetes medication together increases the blood levels of diabetic medicine hence increases the risk of low blood sugar
Antacids
- Taking magnesium and antacid together decreases the laxative effect of magnesium
Gabapentin
- Taking magnesium and gabapentin together decreases the body’s absorption capacity and reduces the drug’s effectiveness
- So, gabapentin must be consumed 2 hours before or 6 hours after magnesium consumption.
Ketamine
- Taking high doses of magnesium and ketamine together increases the side effects of the drug
Sevelamer
- Taking magnesium and sevelamer together increases the risk of very high magnesium levels in the body18Interactions | Researched based study from Nlm.nih.gov
Interaction with other supplements
Calcium tablet
- Taking magnesium and calcium together reduces the body’s capacity to absorb calcium
Multivitamin supplement containing iron and zinc
- Taking magnesium and multivitamin with iron and zinc decreases the absorption of iron and zinc in the body19Interactions | Researched based study from Nlm.nih.gov
- It reduces the efficiency of the multivitamin supplement
Takeaway
Key Takeaways
- Magnesium is an essential macronutrient in many bodily processes such as nerve, muscle, and bone.
- Magnesium deficiencies can lead to several health problems
- Magnesium supplements are available in health stores for magnesium-deficient individuals
- One should always consult a physician before including magnesium supplements in their diet to get the correct dose and to avoid the risk of overdose
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References
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Science Direct
Magnesium in Disease Prevention and Overall Health | Overview | Sources
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National Library of Medicine
Magnesium in man: implications for health and disease | Overview
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National Institutes of Health
Magnesium-Fact Sheet for Health Professionals | Dosage
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National Library of Medicine
Magnesium Intake, Quality of Carbohydrates, and Risk of Type 2 Diabetes: Results From Three U.S. Cohorts | Benefits
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National Library of Medicine
Effect of magnesium supplementation on depression status in depressed patients with magnesium deficiency: A randomized, double-blind, placebo-controlled trial | Benefits
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National Library of Medicine
Comparison of therapeutic effects of magnesium sulfate vs. dexamethasone/metoclopramide on alleviating acute migraine headache | Benefits
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National Library of Medicine
Dietary Magnesium Is Positively Associated With Skeletal Muscle Power and Indices of Muscle Mass and May Attenuate the Association Between Circulating C-Reactive Protein and Muscle Mass in Women | Benefits
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National Library of Medicine
Effect of Magnesium Supplementation on Plasma C-reactive Protein Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | Benefits
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National Library of Medicine
Impact of magnesium on bone health in older adults: A systematic review and meta-analysis | Benefits
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National Library of Medicine
Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies | Benefits
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National Library of Medicine
Effects of Magnesium and Vitamin B6 on the Severity of Premenstrual Syndrome Symptoms' | Benefits
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National Library of Medicine
Role of magnesium supplementation in the treatment of depression: A randomized clinical trial | Benefits
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National Library of Medicine
Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study | Benefits
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National Library of Medicine
Magnesium and Human Health: Perspectives and Research Directions - PMC | Side effects
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National Library of Medicine
Magnesium Toxicity | Overdose toxicity
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National Library of Medicine
Magnesium deficiency: Does it have a role to play in cataractogenesis? | Deficiency
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National Institutes of Health
Magnesium-Fact Sheet for Health Professionals | Deficiency
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National Library of Medicine
Magnesium and Drugs | Interactions
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National Library of Medicine
Magnesium Sulfate | Interactions