Emgality: Uses, Side effects and Precautions

Research Based
Medically reviewed by - Dr. Abdul Khalique, MD Written by - Dr. Diksha Sangle


What is Emgality?

Emgality is a prescription drug used to treat adult migraine headaches before they occur. Galcanezumab, the drug’s main component, is a member of the group of medications known as calcitonin gene-related peptide inhibitors.

Millions of people get migraine headaches yearly, which are extremely painful and negatively influence the quality of life.

This article explores its key features, highlighting its action method, effectiveness, administration, and potential benefits.

Emgality is a prescription drug used to treat adult migraine headaches before they occur. Galcanezumab, the drug's main component, is a member of the group of medications known as calcitonin gene-related peptide inhibitors.

What is Migraine?

A neurological illness known as migraine headaches is characterized by frequent, severe, and throbbing headaches primarily affecting one side of the brain. Other signs and symptoms are also frequently experienced, such as nausea, vomiting, and sensitivity to light and sound. It may seriously interfere with daily tasks and be exceedingly debilitating, lowering the quality of life for affected people.

Remembering that migraines are a complex disorder with numerous causes and contributing factors is essential.


Uses of Emgality

The primary uses comprise:

  • Prevention of migraines
  • Reducing the frequency and intensity of chronic migraines.

Prevention of Migraines

  • For patients who get recurrent migraines, it is prescribed as a preventative measure. It is specially made to lessen the frequency and severity of migraine attacks, improving the patient’s quality of life.

Reducing the frequency and intensity of chronic migraines

  • It’s important to remember that Emgality is not meant to treat acute migraines or ease symptoms while an attack continues. Its goal is to reduce or prevent the frequency of migraines eventually.1Uses| Researched based study from ,2Uses| Researched based study from

How does Emgality work?

  • It works by focusing on and inhibiting the action of CGRP, a protein known to be involved in migraines. It helps modify the neurological processes linked to them by inhibiting CGRP, which reduces their occurrence.2Uses| Researched based study from


Dosage of Emgality

Usually, a subcutaneous injection is administered just beneath the skin. It is available for self-administration in prefilled pens or syringes after receiving the necessary training and instructions from a healthcare practitioner.


  • Wash your hands thoroughly in soap and water before giving. The syringe or pen, alcohol swabs, and a sharps container should all be collected to dispose of old needles safely.

Choose an injection site.

  • The fatty tissue immediately below the skin is where it is injected. The upper thigh, belly (except a 2-inch region surrounding the navel), or upper arm is typical injection locations. To help avoid adverse reactions, rotate the injection site after each dose.

Clean the area.

  • Clean the selected area with an alcohol swab, then let it air dry.

Prepare the pen or syringe.

  • Remove the cap from the syringe if you use one, and then check the liquid inside. Make sure it is transparent and colorless. Remove the pen cap if you’re using one.

Administer the injection

  • Hold the syringe or pen like a pencil or dart according to the instructions included with the particular gadget.
  • When using a syringe or pen, gently pinch the cleansed skin region before gently inserting the needle at a 45- or 90-degree angle into the fatty tissue.
  • To inject the medication, push the plunger or the button.
  • Keep the syringe or pen in place briefly to ensure it is delivered completely.

Get rid of the used needle or pen.

  • After usage, put the discarded needle or pen in the sharps container. Avoid recapping the needle.2Dosage| Researched based study from

Side effects

Side effects of Emgality.

Side effects of Emgality

Mild side effects

At injection site reaction may causes:

  • Pain
  • Swelling
  • Redness
  • Itching or bruising.

These reactions are usually mild and transient.

Severe side effects

Allergic reactions-Signs of an allergic reaction may include:

  • Hives
  • Itching
  • Rash
  • Difficulty breathing
  • Swelling of the face, lips, tongue, or throat.1Side effects| Researched based study from

It is essential to seek prompt medical help if any of these symptoms arise. It’s important to remember that the mentioned list does not contain all potential adverse effects. Individual responses to medication may differ, and other less frequent side effects could also occur. If troubling signs develop, a healthcare professional should be consulted about potential side effects.

Although the adverse effects that are now known are often minor and short-lived, it is always important to be cautious and report any worries or unexpected symptoms.


Precautions and warnings


  • Let your doctor know if you have any known allergies, especially to galcanezumab or any other components. Although rare, allergic responses can happen.

Pregnant women and nursing mothers

  • Talk to your healthcare provider if you are breastfeeding, pregnant, or planning a pregnancy.
  • Before beginning treatment, weighing the potential risks and benefits is essential, as safe during pregnancy and lactation has not been proven.

Kidney or liver disease

  • Inform your physician if you experience any liver or renal problems. Since the liver is the organ that metabolizes it largely, using it in persons who have significant liver damage may call for caution.
  • Based on the state of the kidneys, there should be no dosage modification.


  • It might weaken the immune system, which might make infections more likely. Inform your doctor immediately if you experience any infection-related symptoms, such as fever, chills, a cough, or discomfort with your urinary system.

Hypersensitivity reactions

  • Hypersensitivity reactions such as redness, itching, and hives have been observed while being uncommon. In case that you experience any of these, please seek emergency medical attention.

Use by children

  • It is presently only approved for usage in adults; the safety and effectiveness have yet to be verified in children and adolescents under 18.


  • While using this drug or any other prescription, it is typically advised to avoid or reduce alcohol consumption. It may interact with medications, reducing their efficacy or the chance of adverse effects.
  • Additionally, for some people, alcohol itself might be a migraine trigger. It could interfere with sleep cycles and cause dehydration, worsening the symptoms.1Precautions| Researched based study from

What happens if you stop taking Emgality?

Rebound migraines

  • Migraine attacks may return if you stop taking your medication. This is possible since it might lessen the frequency and intensity of migraines, thus stopping it might cause your prior migraine patterns to reappear.

Symptoms of withdrawal

  • Some people may develop fatigue, headaches, nausea, and other withdrawal symptoms.

Loss of the preventive effect

  • It is meant to be used frequently as a migraine prevention measure. If you stop taking it, you risk losing the therapeutic benefit it offers in lowering migraine frequency and severity.


Medicine interactions

Other CGRP blockers

  • Combining several CGRP inhibitors, like Emgality, with other drugs from the same class may raise the risk of side effects without adding any extra benefits.
  • As a result, combining various CGRP inhibitors is generally not advised.

Blood thinners (anticoagulants)

  • Although it is unknown whether it directly interacts with anticoagulant drugs, it is still vital to let your doctor know if you take blood thinners so they can evaluate the possibility of an interaction and modify your treatment plan as necessary.

The liver metabolizes various other drugs.

  • The liver’s metabolic processes help the body get rid of legality. As a result, medications that are metabolized by the same liver enzymes may interact with one another.
  • Examples include certain antibiotics, antiepileptic medicines, and antifungal treatments.

Before beginning therapy, you must review all supplements and medications with your doctor.1Interactions| Researched based study from


Emgality alternatives


  • Another CGRP antagonist with FDA approval for adult migraine prophylaxis is this one.3Alternatives| Researched based study from


  • Additionally, Ajovy is employed in the prevention of migraines. Both monthly and quarterly injectable formulations are offered.


  • It is given intravenously infusion-style. Usually, it is administered every three months.4Alternatives| Researched based study from


  • Adults with persistent migraines (15 or more headache days per month) may receive Botox injections. It is injected into particular head and neck muscles, and it acts by preventing the release of several molecules that are involved in pain signalling.


  • It is an oral medication that is occasionally administered to treat migraines. Although it is not a CGRP antagonist, it may help in lowering the frequency and severity.5Alternatives| Researched based study from ,6Alternatives| Researched based study from

Bottom Line

The bottom line

Emgality is a revolutionary development in the management of recurrent migraines. by focusing on the function of CGRP in the course of migraines For those who experience the ongoing hardship and disturbance caused, it provides new hope.

It has the potential to significantly enhance the quality of life for those who suffer from chronic migraines, giving them the ability to regain control and lead happier lives as continuing research continues to reveal its efficacy and safety profile.

Disclaimer: The user acknowledges that this article's information is being offered for informational purposes only. Every attempt has been made to guarantee that the article is informational and correct. If they have any doubts or questions about their health, we firmly advise our readers to visit a doctor or other healthcare professional.

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