Apriso: Uses, Interaction and Side effects

Research Based
Medically reviewed by - Dr Rabia Akram, MD Written by - Dr. Diksha Sangle


About apriso

The introduction of Apriso brings in a new age of hope for people worldwide suffering from chronic inflammatory diseases. It was created as a cutting-edge pharmaceutical remedy and has attracted much interest for its ability to lessen the symptoms of these crippling conditions.

This article introduces the drug and discusses its therapeutic advantages, method of action, and potentially life-changing effects on patients.1Overview| Researched based study from

The introduction of Apriso brings in a new age of hope for people worldwide suffering from chronic inflammatory diseases.


What are the uses of Apriso?

It is primarily used to treat chronic inflammatory diseases, particularly ulcerative colitis. Here are the critical applications:

Ulcerative colitis

  • The U.S. Food and Drug Administration (FDA) has approved this medication for the induction and maintenance of remission in people with mild to moderately active ulcerative colitis. A chronic inflammatory bowel illness, it eases symptoms and promotes remission by causing inflammation in the digestive tract.1Uses| Researched based study from

Maintenance therapy

  • Furthermore, it is used in individuals with ulcerative colitis who have achieved remission to avoid recurrence. It helps to maintain the improved state and reduce the likelihood of illness flare-ups by retaining the use.1Uses| Researched based study from

Side effects

What are the side effects?

It’s essential to remember that not every patient will experience them, and some people can have different reactions. For specific advice, it is always advised to speak with a doctor.

  • Digestive issues
  • Headache
  • Allergic reactions
  • Liver problems
  • Worsening of colitis

Gastrointestinal effects

  • These may include abdominal pain, diarrhea, nausea, vomiting, flatulence (excessive gas), and gastrointestinal discomfort. These are usually mild to moderate and often subside with continued use.


  • While using the medication, some people may suffer headaches. These are generally temporary and can be managed with over-the-counter pain relievers.

Allergic reactions

  • Rarely, it may result in allergic responses. Rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, and breathing difficulties are possible symptoms. It is important to seek quick medical assistance if any allergic symptoms arise.

Liver effects

  • It may rarely affect liver function. Symptoms of liver problems can include yellowing of the skin or eyes, dark urine, persistent nausea or vomiting, or abdominal pain.

Worsening of colitis

  • Although uncommon, it may rarely cause a worsening of symptoms or flare-ups in patients with ulcerative colitis. If you experience increased symptoms, such as abdominal pain, rectal bleeding, or fever, you should seek medical help.2Side effects| Researched based study from

Serious side effects

Some serious events are:


  • Anaphylaxis, a severe allergic reaction, can happen on occasion. Breathing issues, pressure in the chest, facial, lip, tongue, or throat swelling, and hives are among the symptoms that might occur.

Heart conditions, including pericarditis and myocarditis

  • The active component of Apriso, mesalamine, has been linked to a rare disease. Constipation, cramps, acute inflammation, and potentially severe consequences, including heart disorders, can all be signs of it.2Side effects| Researched based study from

Liver injury

  • It has been connected to issues with the liver, including jaundice and hepatotoxicity (liver damage).

Kidney issues

  • Renal dysfunction and interstitial nephritis can happen. Some indications include lower back discomfort, swelling in the legs or ankles, changes in urine frequency or color, and reduced urine production.2Side effects| Researched based study from


What is the correct dose to take?

The usual dosage is four capsules (1.5 grams) taken daily on an empty stomach, at least an hour before breakfast. The capsules shouldn’t be opened, chewed, or crushed; they should be consumed whole.2Dosage| Researched based study from

How long should Apriso be taken?

  • It is utilized as a maintenance treatment to avoid relapse and sustain remission. Your doctor will decide the time frame depending on your unique needs and how the drug works.

Following the directions

  • Following your healthcare provider’s advised dose and regimen is essential. You need to consult your doctor before changing the amount.2Dosage| Researched based study from

What if I miss a dose?

  • If you need to remember to take a dosage, do so right away unless it is almost time for your next dose. Skip the missing amount and go on with your usual dosage regimen.2Dosage| Researched based study from


What should be taken into account before taking Apriso?

Before starting Apriso, ensure your doctor is aware of your medical history. The following are some situations that may call for extra care or close monitoring:

Hypersensitivity or Allergic responses

  • It should not be taken if you are known to be allergic or hypersensitive to other drugs, particularly amino salicylates.

Kidney issues

  • The kidneys are the primary organs used to remove apriso. Your doctor may need to change the dosage or carefully monitor your renal function if you have compromised kidney function.

Liver issues

  • Those with liver illness or impaired liver function should use caution when using the medication because it may impact liver function.

Gastrointestinal disorders

  • The absorption or distribution may be impacted by certain diseases, including pyloric stenosis (narrowing of the path between the stomach and small intestine) or reduced gastric emptying.

A history of heart disease

  • Although Apriso is not known to affect the heart directly, those with heart issues, including congestive heart failure or a history of pericarditis, should be monitored closely.

Additional medical issues

  • Any other medical issues, such as blood disorders, pancreatitis, etc., should be disclosed to your doctor.2Precautions| Researched based study from

How does Apriso reacts with alcohol?

  • Alcohol and apriso both have the potential to upset the digestive system. The likelihood of gastric problems rises. Additionally, drinking alcohol can put a strain on the liver and can impair how well it functions. Combining it with alcohol may make the liver work harder and worsen liver-related adverse effects.2Precautions| Researched based study from
  • Drinking alcohol can affect how some medications are absorbed and processed.

Apriso in pregnant and breastfeeding women

  • Studies on pregnancy use in prison have not shown an increased risk of congenital disabilities, as the data is limited.
  • If you are pregnant or planning to become pregnant, it is essential to consult your doctor before taking it. They will assess the potential risks and benefits in your specific situation. Your doctor will consider the severity of your condition and may explore alternative options.

In nursing mothers

  • It is essential to monitor your baby for any signs of adverse effects, such as changes in stool patterns, feeding difficulties, or unusual irritability. It is essential that you consult with a medical expert who has access to your whole medical file and can make customized recommendations.2Precautions| Researched based study from


What happens if I have an overdose of Apriso?

  • Nausea and vomiting
  • Abdominal pain or discomfort
  • Diarrhea
  • Headache
  • Dizziness
  • Fatigue or weakness
  • Confusion or disorientation
  • Difficulty breathing

In severe cases, overdosing might result in blood or renal problems. A prompt medical examination is essential to determine the severity of the overdose and administer the appropriate therapy.

Treatment for overdoses may entail thorough monitoring of vital signs while also providing supportive care to address symptoms.2Overdose| Researched based study from


How does it interact with other medicines?


  • The risk of renal issues may increase if Apriso is used concurrently with medications impairing kidney function, such as nonsteroidal anti-inflammatory drugs like ibuprofen or naproxen.3Interactions| Researched based study from

Sulfasalazine-containing medications

  • It shouldn’t be used simultaneously with medications that contain sulfasalazine since doing so may make adverse effects more likely.6Interactions| Researched based study from

6-mercaptopurine or azathioprine

  • Combining these medications may make blood problems more likely.6Interactions| Researched based study from

Anticoagulants (blood thinners)

  • There may be an increase in the blood coagulant effects of drugs like warfarin, which might result in a higher risk of bleeding.4Interactions| Researched based study from

Drugs that suppress the immune system

  • The immune system may be impacted by apriso, and using it together with other immunosuppressive drugs such as corticosteroids or methotrexate may raise the risk of infections.5Interactions| Researched based study from

Medicines that alter the stomach pH

  • Proton pump inhibitors or antacids may interfere with Apriso’s ability to release and absorb mesalamine.6Interactions| Researched based study from



A prescription drug called Apriso is frequently used to treat ulcerative colitis. It has shown success in treating the disorder. But taking the medication as directed is crucial, and a doctor should be consulted for the right advice. Although it has demonstrated effectiveness in controlling the symptoms, individual reactions may differ, and possible dangers should be considered.

Disclaimer: The user acknowledges that this article's information is being offered for informational purposes only. Every attempt has been made to guarantee that the article is informational and correct. If they have any doubts or questions about their health, we firmly advise our readers to visit a doctor or other healthcare professional.

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